6664 replies
  1. Josh Bachynski
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    For most patients, the really helpful beginning dose of LEVITRA is 10 mg, taken orally,
    as wanted, roughly 60 minutes earlier than sexual exercise.

    The dose could also be elevated to a most advisable dose of 20 mg
    or decreased to 5 mg based mostly on efficacy and unintended effects.
    The utmost really useful dosing frequency is as soon as per
    day. Sexual stimulation is required for a response to therapy.

    Use With Meals

    Geriatrics

    A beginning dose of 5 mg LEVITRA needs to be thought-about in patients >=
    Sixty five years of age [seeUse In Particular Populations].

    For patients with reasonable hepatic impairment (Baby-Pugh B), a beginning dose of 5 mg LEVITRA is really useful.

    The utmost dose in patients with reasonable hepatic impairment mustn’t exceed 10
    mg.

    Do not use LEVITRA in patients with extreme hepatic impairment (Baby-Pugh C) [see WARNINGS AND PRECAUTIONS,Use in Particular Populations andCLINICAL PHARMACOLOGY].

    Do not use LEVITRA in patients on renal dialysis [see WARNINGS AND PRECAUTIONS,Use In Particular Populations andCLINICAL PHARMACOLOGY].

    Concomitant Medications

    Concomitant use with nitrates and nitric oxide donors in any type is contraindicated [seeCONTRAINDICATIONS].

    Guanylate Cyclase (GC) Stimulators, equivalent to riociguat

    Concomitant use is contraindicated [see CONTRAINDICATIONS].

    CYP3A4 Inhibitors

    The dosage of LEVITRA might require adjustment in patients receiving potent CYP3A4 inhibitors akin to ketoconazole,
    itraconazole, ritonavir, indinavir, saquinavir, atazanavir, and clarithromycin in addition to in different patients receiving reasonable CYP3A4 inhibitors reminiscent of erythromycin [see DRUG INTERACTIONS].
    For ritonavir, a single dose of two.5 mg LEVITRA shouldn’t be exceeded in a seventy two-hour interval.
    For indinavir, saquinavir, atazanavir, ketoconazole four hundred mg day by day, itraconazole four hundred mg each day, and clarithromycin, a single dose of two.5 mg LEVITRA shouldn’t be
    exceeded in a 24-hour interval. For ketoconazole 200
    mg every day, itraconazole 200 mg every day, and erythromycin, a single dose of 5 mg LEVITRA
    shouldn’t be exceeded in a 24-hour interval.

    Alpha-Blockers

    In these patients who’re stable on alpha-blocker therapy, phosphodiesterase kind 5 (PDE5) inhibitors
    must be initiated at the bottom really helpful beginning
    dose. Concomitant therapy must be initiated provided that the affected person is stable on his
    alpha-blocker therapy. Stepwise improve in alpha-blocker dose could also be related to additional decreasing of blood strain in patients taking a phosphodiesterase (PDE5) inhibitor together with
    vardenafil. In these patients who’re stable on alpha-blocker therapy,
    LEVITRA ought to be initiated at a dose of 5 mg (2.5
    mg when used concomitantly with sure CYP3A4 inhibitors).

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